Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study
نویسندگان
چکیده
منابع مشابه
A Modified Controlled Cortical Impact Technique to Model Mild Traumatic Brain Injury Mechanics in Mice
For the past 25 years, controlled cortical impact (CCI) has been a useful tool in traumatic brain injury (TBI) research, creating injury patterns that includes primary contusion, neuronal loss, and traumatic axonal damage. However, when CCI was first developed, very little was known on the underlying biomechanics of mild TBI. This paper uses information generated from recent computational model...
متن کاملControlled cortical impact model for traumatic brain injury.
Every year over a million Americans suffer a traumatic brain injury (TBI). Combined with the incidence of TBIs worldwide, the physical, emotional, social, and economical effects are staggering. Therefore, further research into the effects of TBI and effective treatments is necessary. The controlled cortical impact (CCI) model induces traumatic brain injuries ranging from mild to severe. This me...
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Secondary insults can adversely influence outcome following severe traumatic brain injury. Monitoring of cerebral extracellular chemistry with microdialysis has the potential for early detection of metabolic derangements associated with such events. The objective of this study was to determine the relationship between the fundamental biochemical markers and neurological outcome in a large cohor...
متن کاملThe Concentration of Soluble Extracellular Amyloid-β Protein in Acute Brain Slices from CRND8 Mice
BACKGROUND Many recent studies of the effects of amyloid-β protein (Aβ) on brain tissue from amyloid precursor protein (APP) overexpressing mice have concluded that Aβ oligomers in the extracellular space can profoundly affect synaptic structure and function. As soluble proteins, oligomers of Aβ can diffuse through brain tissue and can presumably exit acute slices, but the rate of loss of Aβ sp...
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Severe traumatic brain injury (TBI), defined as patients with a Glasgow Coma Scale (GCS) score ≤ 8, is a well-known cause of life-long disability and death. TBI is commonly observed in young adults although the incidence of elderly people is increasing. TBI has also been identified as an important environmental risk factor for the development of Alzheimer ́s disease (AD) later in life. Amyloid-β...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2010
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2010.06.018